| Rank | Player | Team | Assists |
| 1 | P. Kane | CHI | 51 |
| 2 | R. Lang | 33 | |
| 3 | J. Toews | CHI | 30 |
| 4 | P. Sharp | CHI | 26 |
| 5 | J. Williams | 23 | |
| 6 | B. Seabrook | CHI | 23 |
| 7 | D. Keith | CHI | 20 |
| 8 | J. Wisniewski | CBJ | 19 |
| 9 | B. Sopel | 19 | |
| 10 | D. Byfuglien | WPG | 17 |
| 11 | M. Havlat | SJS | 17 |
| 12 | T. Ruutu | CAR | 15 |
| 13 | R. Bourque | MTL | 14 |
| 14 | D. Bolland | CHI | 13 |
| 15 | C. Barker | VAN | 12 |
| 16 | A. Ladd | WPG | 7 |
| 17 | J. Vandermeer | VAN | 7 |
| 18 | Y. Perreault | 5 | |
| 19 | P. Kontiola | 5 | |
| 20 | A. Burish | SJS | 4 |